Which language do you prefer?
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It really depends on what you wish to do with it. If you're doing web development, JS is of course for the frontend, and Node.js/Python can be used for the backend, but personally I prefer node.js. Besides, Node.js can also be used to produce desktop apps (with Electron) or mobile apps (with React Native), and it turns out that using Node.js is as good as using those language which are for those aspects. On the other hand, if you want language which is quicker to get your job done, or a lot of data processing is involved in your job, Python is a better choice.
Not sure, I was learning both. It's said that Python is good for beginners, but I like NodeJs and I was told as a designer it's more important to learn JS. So I think it depends on what do you want to do, and how you'd like to use it.