We're toying around with remi: a platform-independent Python GUI framework.
It works on Repl.it because it renders to HTML. Events are sent back to the Python program via Websockets to react to. It's a pretty neat idea and surprisingly faster than I expected.
It's perfect for people who have learned Python but haven't done web development yet (which is relatively more complex and takes time to get into).
Here is the source: https://repl.it/@amasad/tictactoe